Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial.

ABSTRACT:

Importance

Intraoperative electroencephalogram (EEG) waveform suppression, suggesting excessive general anesthesia, has been associated with postoperative delirium.

Objective

To assess whether EEG-guided anesthesia decreases the incidence of delirium after cardiac surgery.

Design, setting, and participants

Randomized, parallel-group clinical trial of 1140 adults 60 years or older undergoing cardiac surgery at 4 Canadian hospitals. Recruitment was from December 2016 to February 2022, with follow-up until February 2023.

Interventions

Patients were randomized in a 1:1 ratio (stratified by hospital) to receive EEG-guided anesthesia (n = 567) or usual care (n = 573). Patients and those assessing outcomes were blinded to group assignment.

Main outcomes and measure

SUBMITTER: Deschamps A 

PROVIDER: S-EPMC11165413 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature