Registry-based randomised controlled trials: conduct, advantages and challenges-a systematic review.

ABSTRACT:

Background

Registry-based randomised controlled trials (rRCTs) have been described as pragmatic studies utilising patient data embedded in large-scale registries to facilitate key clinical trial procedures including recruitment, randomisation and the collection of outcome data. Whilst the practice of utilising registries to support the conduct of randomised trials is increasing, the use of the registries within rRCTs is inconsistent. The purpose of this systematic review is to explore the conduct of rRCTs using a patient registry to facilitate trial recruitment and the collection of outcome data, and to discuss the advantages and challenges of rRCTs.

Methods

A systematic search of the literature was conducted using five databases from inception to June 2020: PubMed, Embase (

SUBMITTER: Shiely F 

PROVIDER: S-EPMC11165819 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature