Integrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer.

ABSTRACT:

Background

Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.

Methods

We examined the relationship between genetically determined levels of plasma proteins and PC through a systemic proteome-wide Mendelian randomization (MR) analysis utilizing cis-pQTLs from multiple centers. Rigorous sensitivity analyses, colocalization, reverse MR, replications with varying instrumental variable selections and additional datasets, as well as subsequent meta-analysis, were utilized to confirm the robustness of significant findings. The causative effect of corresponding protein-coding genes' expression and their expression pattern in single-cell types were then investigated. Enrichment analysis, b

SUBMITTER: Zhou S 

PROVIDER: S-EPMC11165868 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature