Use of HBV RNA and to predict change in serological status and disease activity in CHB.

ABSTRACT:

Background and aims

Predicting changes in disease activity and serological endpoints is necessary for the management of patients with chronic hepatitis B (CHB). We examined whether HBV RNA and hepatitis B core-related antigen (HBcrAg), two specialized virological markers proposed to reflect the activity of covalently closed circular DNA, may improve the ability to predict not sustained inactive carrier phase, spontaneous alanine aminotransferase (ALT) flare, HBeAg loss, and HBsAg loss.

Approach and results

Among eligible participants enrolled in the North American Hepatitis B Research Network Adult Cohort Study, we evaluated demographic, clinical, and virologic characteristics, including HBV RNA and HBcrAg, to predict not sustained inactive carrier phase, ALT flare, HBeAg lo

SUBMITTER: Ghany MG 

PROVIDER: S-EPMC11165989 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature