Risks and benefits of pre-delivery taper in pregnant women taking antidepressants.

ABSTRACT:

Background

Serotonin reuptake inhibitors are commonly used for treatment of mental health problems in pregnancy but may cause neonatal adaptation syndrome. It is unknown whether reduction or discontinuation of medication prior to delivery may mitigate this effect.

Methods

We present a case series of 38 women who either tapered their medication prior to delivery or maintained or increased their dose.

Results

Greater reductions in maternal antidepressant dose just prior to delivery were associated with fewer admissions to the neonatal intensive care unit (NICU) for infants. There was a slightly greater increase in depressive symptoms across delivery for women who tapered, which was not statistically significant.

Conclusions

NICU admissions may be less frequent am

SUBMITTER: Robakis TK 

PROVIDER: S-EPMC11166172 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature