Acute promyelocytic leukemia in children cancer hospital Egypt.

ABSTRACT:

Background

Pediatric acute promyelocytic leukemia (APL) accounts for 5 to 15% of all myelocytic leukemia. A retrospective analysis of pediatric patients diagnosed and treated with APL was conducted at CCHE from July 2012 to the end of December 2019, to report the prevalence, clinical characteristics, results, and risk factors associated with induction failure and early death.

Result

Sixty-two patients were reported, with an age greater than ten, an initial poor coagulation profile, and a total leukocyte count (TLC) greater than 30 10³/mm³ influencing 5-year overall (OS) and event-free survival (EFS), as well as a high promyelocyte count affecting 5-year EFS. Patients received a regimen based on the COG AAML0631 protocol. High-risk patients with an initi

SUBMITTER: Semary S 

PROVIDER: S-EPMC11166612 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature