¹H-NMR-based metabolomics reveals the preventive effect of <i>Enteromorpha prolifera</i> polysaccharides on diabetes in Zucker diabetic fatty rats.

ABSTRACT: The primary objective of this investigation was to explore the beneficial impacts of Enteromorpha prolifera polysaccharide (EP) on dysglycemia in Zucker diabetic fatty (ZDF) rats, while also shedding light on its potential mechanism using ¹H-NMR-based metabolomics. The results demonstrated a noteworthy reduction in fasting blood glucose (FBG, 46.3%), fasting insulin (50.17%), glycosylated hemoglobin A1c (HbA1c, 44.1%), and homeostatic model assessment of insulin resistance (HOMA-IR, 59.75%) following EP administration, while the insulin sensitivity index (ISI, 19.6%) and homeostatic model assessment of β-cell function (HOMA-β, 2.5-fold) were significantly increased. These findings indicate that EP enhances β-cell function, increases insulin sensitivity, and improves insul

SUBMITTER: Chen J 

PROVIDER: S-EPMC11167149 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature