Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis.

ABSTRACT:

Background

The association between Apolipoprotein A5 (APOA5) genetic polymorphisms and susceptibility to metabolic syndrome (MetS) has been established by many studies, but there have been conflicting results from the literature. We performed a meta-analysis of observational studies to evaluate the association between APOA5 gene polymorphisms and the prevalence of MetS.

Methods

PubMed, Web of Science, Embase, and Scopus were searched up to April 2024. The random effects model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CI) of the association between APOA5 gene polymorphisms and the prevalence of MetS development. The potential sources of heterogeneity were evaluated by subgroup analyses and sensitivity analyses.

Results

A total of 30 studi

SUBMITTER: Mozafari S 

PROVIDER: S-EPMC11167842 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature