Circadian photoentrainment varies by season and depressed state: associations between light sensitivity and sleep and circadian timing.

ABSTRACT:

Study objectives

Altered light sensitivity may be an underlying vulnerability for disrupted circadian photoentrainment. The photic information necessary for circadian photoentrainment is sent to the circadian clock from melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The current study tested whether the responsivity of ipRGCs measured using the post-illumination pupil response (PIPR) was associated with circadian phase, sleep timing, and circadian alignment, and if these relationships varied by season or depression severity.

Methods

Adult participants (N = 323, agem = 40.5, agesd = 13.5) with varying depression severity were recruited during the summer (n = 154) and winter (n = 169) months. Light sensitivity was measured using the PIPR. Ci

SUBMITTER: Wescott DL 

PROVIDER: S-EPMC11168757 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature