Molecular mechanism of choline and ethanolamine transport in humans.

ABSTRACT: Human feline leukaemia virus subgroup C receptor-related proteins 1 and 2 (FLVCR1 and FLVCR2) are members of the major facilitator superfamily¹. Their dysfunction is linked to several clinical disorders, including PCARP, HSAN and Fowler syndrome^2-7. Earlier studies concluded that FLVCR1 may function as a haem exporter^8-12, whereas FLVCR2 was suggested to act as a haem importer¹³, yet conclusive biochemical and detailed molecular evidence remained elusive for the function of both transporters^14-16. Here, we show that FLVCR1 and FLVCR2 facilitate the transport of choline and ethanolamine across the plasma membrane, using a concentration-driven substrate translocation process. Through structural and computational analyses, we have identif

SUBMITTER: Ri K 

PROVIDER: S-EPMC11168923 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature