Senescent glia link mitochondrial dysfunction and lipid accumulation.

ABSTRACT: Senescence is a cellular state linked to ageing and age-onset disease across many mammalian species^1,2. Acutely, senescent cells promote wound healing^3,4 and prevent tumour formation⁵; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. Whereas senescent cells are active targets for anti-ageing therapy^6-11, why these cells form in vivo, how they affect tissue ageing and the effect of their elimination remain unclear^12,13. Here we identify naturally occurring senescent glia in ageing Drosophila brains and decipher their origin and influence. Using Activator protein 1 (AP1) activity to screen for senescence^14,15, we determine that senescent glia can appear in response to neuronal mitochondrial dysfu

SUBMITTER: Byrns CN 

PROVIDER: S-EPMC11168935 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature