The sex of organ geometry.

ABSTRACT: Organs have a distinctive yet often overlooked spatial arrangement in the body^1-5. We propose that there is a logic to the shape of an organ and its proximity to its neighbours. Here, by using volumetric scans of many Drosophila melanogaster flies, we develop methods to quantify three-dimensional features of organ shape, position and interindividual variability. We find that both the shapes of organs and their relative arrangement are consistent yet differ between the sexes, and identify unexpected interorgan adjacencies and left-right organ asymmetries. Focusing on the intestine, which traverses the entire body, we investigate how sex differences in three-dimensional organ geometry arise. The configuration of the adult intestine is only partially determined by physical constrai

SUBMITTER: Blackie L 

PROVIDER: S-EPMC11168936 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature