Causal association between particulate matter 2.5 and Alzheimer's disease: a Mendelian randomization study.

ABSTRACT:

Background

Although epidemiological evidence implies a link between exposure to particulate matter (PM) and Alzheimer's disease (AD), establishing causality remains a complex endeavor. In the present study, we used Mendelian randomization (MR) as a robust analytical approach to explore the potential causal relationship between PM exposure and AD risk. We also explored the potential associations between PM exposure and other neurodegenerative diseases.

Methods

Drawing on extensive genome-wide association studies related to PM exposure, we identified the instrumental variables linked to individual susceptibility to PM. Using summary statistics from five distinct neurodegenerative diseases, we conducted two-sample MR analyses to gauge the causal impact of PM on the risk of deve

SUBMITTER: Dang M 

PROVIDER: S-EPMC11169690 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature