Cathepsin-mediated regulation of alpha-synuclein in Parkinson's disease: a Mendelian randomization study.

ABSTRACT:

Objective

The observational association between cathepsin and Parkinson's disease (PD) has been partially explored in previous research. However, the causal relationship remains unclear. In this study, our objective is to investigate the causal link between cathepsin and PD using Mendelian randomization (MR) analysis and elucidate the underlying mechanisms governing their interaction.

Methods

Utilizing bidirectional two-sample MR and multivariable MR, we systematically investigates the causal relationship between nine cathepsins and PD. The data pertaining to cathepsins were obtained from the Integrative Epidemiology Unit (IEU) Open GWAS Project, while data related to PD were sourced from versions R9 and R10 of the FinnGen database. The primary analytical method utilized was

SUBMITTER: Lin L 

PROVIDER: S-EPMC11170285 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature