Polygenic Scores and Networks of Psychopathology Symptoms.

ABSTRACT:

Importance

Studies on polygenic risk for psychiatric traits commonly use a disorder-level approach to phenotyping, implicitly considering disorders as homogeneous constructs; however, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms may shed light on the role of polygenic risk in psychopathology.

Objective

To determine whether polygenic scores are associated with all symptoms of psychiatric disorders or with a subset of indicators and whether polygenic scores are associated with comorbid phenotypes via specific sets of relevant symptoms.

Design, setting, and participants

Data from 2 population-based cohort studies were used in this cross-sectional study. Data from

SUBMITTER: Piazza GG 

PROVIDER: S-EPMC11170456 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature