Expression and prognostic significance of microsomal triglyceride transfer protein in brain tumors: a retrospective cohort study.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common malignant brain tumor and has poor survival. An elevated cholesterol level is involved occurrence and progression of brain tumors. Microsomal triglyceride transfer protein (MTTP) is a target for lowering lipids, and its inhibition helps to improve hyperlipidemia. However, whether the altered expression of MTTP affects the development and prognosis of brain tumors is currently unidentified. The purpose of this study is to determine MTTP as a prognostic marker for brain tumors.

Methods

Data for patients with brain cancers and control brain tissue were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The datasets were analyzed using Mann-Whitney U-test or t-test to compar

SUBMITTER: Son SM 

PROVIDER: S-EPMC11170499 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature