A novel angiogenesis-associated risk score predicts prognosis and characterizes the tumor microenvironment in colon cancer.

ABSTRACT:

Background

Angiogenesis of the tumor microenvironment (TME) can promote the proliferation and metastases of colon cancer (CC). However, there is a lack of bioinformatics analysis to comprehensively clarify the molecular characteristics, immune interaction characteristics and predictive values of angiogenesis characteristics in CC patients. This study aimed to perform a comprehensive elucidation of the correlation between angiogenesis and CC for the purpose of improving the clinical management of CC.

Methods

Angiogenesis-associated genes (AAGs) were evaluated in the population of CC patients from the Cancer Genome Atlas database and Gene Expression Omnibus dataset. The expression, prognostic role, and immune cell infiltration of AAGs were assessed first. And then we establish

SUBMITTER: Li X 

PROVIDER: S-EPMC11170505 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature