CD112 is an epithelial-to-mesenchymal transition-related and immunological biomarker in pan-cancer.

ABSTRACT:

Background

The nectin adhesion molecule CD112, an important component of tumor progression, belongs to the nectin family. However, a comprehensive evaluation of its clinical relevance and mechanism in various cancers is yet to be conducted.

Methods

This investigation fully examined the relationship between prognosis and CD112 expression. We clarified the function of CD112 in tumor immunity by employing The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. This involved examining its connections to tumor mutation burden (TMB), DNA methylation, tumor immune invasion, mismatch repair (MMR), microsatellite instability (MSI), and common immune checkpoint inhibitors (ICIs). Additionally, the impact of CD112 knockdown on cell function was examined in color

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11170512 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature