Propofol regulates the progression of hepatocellular carcinoma via the POLR2L/TGF-β signaling pathway.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. Propofol has been reported to modulate tumorigenesis in HCC; the aim of this study was to investigate the effect of the interaction of propofol with POLR2L on HCC tumor progression in HCC.

Methods

The propofol-related GSE101724 dataset was analyzed using weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEGs) to identify overlapping genes. Key genes were selected from The Cancer Genome Atlas-liver hepatocellular carcinoma (TCGA-LIHC)-DEGs for prognostic analysis. The impact of POLR2L on LIHC patient survival was assessed, followed by in vitro experiments to validated its effects on HCC cell behavior and signaling pathways.

Results

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SUBMITTER: Chen J 

PROVIDER: S-EPMC11170526 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature