APOA1 mRNA and serum APOA1 protein as diagnostic and prognostic biomarkers in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) remains a formidable challenge in oncology, ranking as a leading cause of cancer mortality globally. This underscores an urgent need for innovative prognostic markers that can revolutionize patient management and outcomes. Recent insights into cancer biology have spotlighted the profound influence of lipid metabolism alterations on tumorigenesis, tumor progression, and the tumor microenvironment. These alterations not only fuel cancer cell growth and proliferation but also play a strategic role in evading immune surveillance and promoting metastasis. The intricate web of lipid metabolism in cancer cells, characterized by deregulated uptake, synthesis, and oxidation of fatty acids (FAs), opens new avenues for targeted therapeutic interventions and prog

SUBMITTER: Li F 

PROVIDER: S-EPMC11170536 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature