Distinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis.

ABSTRACT:

Background/purpose(s)

The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut virome in arthritis patients, including osteoarthritis (OA) and gouty arthritis (GA), requires further investigation.

Methods

We employed virus-like particle (VLP)-based metagenomic sequencing to analyze gut viral community in 20 OA patients, 26 GA patients, and 31 healthy controls, encompassing a total of 77 fecal samples.

Results

Our analysis generated 6819 vOTUs, with a considerable proportion of viral genomes differing from existing catalogs. The gut virome in OA and GA patients differed significantly from healthy controls, showing variat

SUBMITTER: Chen CM 

PROVIDER: S-EPMC11170907 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature