CpG island turnover events predict evolutionary changes in enhancer activity.

ABSTRACT:

Background

Genetic changes that modify the function of transcriptional enhancers have been linked to the evolution of biological diversity across species. Multiple studies have focused on the role of nucleotide substitutions, transposition, and insertions and deletions in altering enhancer function. CpG islands (CGIs) have recently been shown to influence enhancer activity, and here we test how their turnover across species contributes to enhancer evolution.

Results

We integrate maps of CGIs and enhancer activity-associated histone modifications obtained from multiple tissues in nine mammalian species and find that CGI content in enhancers is strongly associated with increased histone modification levels. CGIs show widespread turnover across species and species-specific CGIs

SUBMITTER: Kocher AA 

PROVIDER: S-EPMC11170920 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature