Immune and Microbial Signatures Associated with PD-1 Blockade Sensitivity in a Preclinical Model for HPV+ Oropharyngeal Cancer.

ABSTRACT: The United States is suffering from an epidemic associated with high-risk strains of the Human Papillomavirus (HPV) predominantly responsible for the development of head and neck squamous cell carcinoma (HNSCC). Treatment with immune checkpoint inhibitors targeting programmed death 1 (PD-1) or its ligand PD-L1 has shown poor efficacy in HNSCC patients, observing only a 20-30% response. Therefore, biological marker identification associated with PD-1 blockade response is important to improve prognosis and define novel therapeutics for HNSCC patients. Therapy response was associated with increased frequencies of activated CD27⁺T cells, activated CD79a⁺ B cells, antigen-presenting CD74⁺ dendritic and B cells, and PD-L1⁺ and PD-L2⁺ myeloid

SUBMITTER: Diaz-Rivera J 

PROVIDER: S-EPMC11171047 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature