Host sequences flanking the human T-cell leukemia virus type 1 provirus in vivo.

ABSTRACT: Human pathogenic retroviruses do not have common loci of integration. However, many factors, such as chromatin structure, transcriptional activity, DNA-protein interaction, CpG methylation, and nucleotide composition of the target sequence, may influence integration site selection. These features have been investigated by in vitro integration reactions or by infection of cell lines with recombinant retroviruses. Less is known about target choice for integration in vivo. The present study was conducted in order to assess the characteristics of cellular sequences targeted for human T-cell leukemia virus type 1 (HTLV-1) integration in vivo. Sequencing integration sites from >/=200 proviruses (19 kb of sequence) isolated from 29 infected individuals revealed that HTLV-1 integration is not rand

SUBMITTER: Leclercq I 

PROVIDER: S-EPMC111712 | biostudies-literature | 2000 Mar

REPOSITORIES: biostudies-literature