The First Genetic Characterization of the SPRN Gene in Pekin Ducks (Anas platyrhynchos domesticus).

ABSTRACT: Prion diseases are fatal neurodegenerative disorders characterized by an accumulation of misfolded prion protein (PrP^Sc) in brain tissues. The shadow of prion protein (Sho) encoded by the shadow of prion protein gene (SPRN) is involved in prion disease progress. The interaction between Sho and PrP accelerates the PrP^Sc conversion rate while the SPRN gene polymorphisms have been associated with prion disease susceptibility in several species. Until now, the SPRN gene has not been investigated in ducks. We identified the duck SPRN gene sequence and investigated the genetic polymorphisms of 184 Pekin ducks. We compared the duck SPRN nucleotide sequence and the duck Sho protein amino acid sequence with those of several other species. Fin

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC11171214 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature