The Many Roads from Alternative Splicing to Cancer: Molecular Mechanisms Involving Driver Genes.

ABSTRACT: Cancer driver genes are either oncogenes or tumour suppressor genes that are classically activated or inactivated, respectively, by driver mutations. Alternative splicing-which produces various mature mRNAs and, eventually, protein variants from a single gene-may also result in driving neoplastic transformation because of the different and often opposed functions of the variants of driver genes. The present review analyses the different alternative splicing events that result in driving neoplastic transformation, with an emphasis on their molecular mechanisms. To do this, we collected a list of 568 gene drivers of cancer and revised the literature to select those involved in the alternative splicing of other genes as well as those in which its pre-mRNA is subject to alternative splicing, w

SUBMITTER: Gimeno-Valiente F 

PROVIDER: S-EPMC11171328 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature