Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.

ABSTRACT: Methyl-CpG-binding protein 2 (Mecp2) is an epigenetic modulator and numerous studies have explored its impact on the central nervous system manifestations. However, little attention has been given to its potential contributions to the peripheral nervous system (PNS). To investigate the regulation of Mecp2 in the PNS on specific central regions, we generated Mecp2^fl/flAdvillin^cre mice with the sensory-neuron-specific deletion of the Mecp2 gene and found the mutant mice had a heightened sensitivity to temperature, which, however, did not affect the sense of motion, social behaviors, and anxiety-like behavior. Notably, in comparison to Mecp2^fl/fl mice, Mecp2^fl/flAdvillin^cre mice exhibited improved

SUBMITTER: Feng Y 

PROVIDER: S-EPMC11171598 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature