Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer.

ABSTRACT: Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apo

SUBMITTER: Gusson-Zanetoni JP 

PROVIDER: S-EPMC11172343 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature