Arginine Regulates Skeletal Muscle Fiber Type Formation via mTOR Signaling Pathway.

ABSTRACT: The composition of skeletal muscle fiber types affects the quality of livestock meat and human athletic performance and health. L-arginine (Arg), a semi-essential amino acid, has been observed to promote the formation of slow-twitch muscle fibers in animal models. However, the precise molecular mechanisms are still unclear. This study investigates the role of Arg in skeletal muscle fiber composition and mitochondrial function through the mTOR signaling pathway. In vivo, 4-week C56BL/6J male mice were divided into three treatment groups and fed a basal diet supplemented with different concentrations of Arg in their drinking water. The trial lasted 7 weeks. The results show that Arg supplementation significantly improved endurance exercise performance, along with increased SDH enzyme activit

SUBMITTER: Zhou M 

PROVIDER: S-EPMC11173221 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature