Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors.

ABSTRACT:

Background

While dysregulated sphingolipid metabolism has been associated with risk of childhood asthma, the specific sphingolipid classes and/or mechanisms driving this relationship remain unclear. We aimed to understand the multifaceted role between sphingolipids and other established asthma risk factors that complicate this relationship.

Methods

We performed targeted LC-MS/MS-based quantification of 77 sphingolipids in plasma from 997 children aged 6 years from two independent cohorts (VDAART and COPSAC₂₀₁₀ ). We examined associations of circulatory sphingolipids with childhood asthma, lung function, and three asthma risk factors: functional SNPs in ORMDL3, low vitamin D levels, and reduced gut microbial maturity. Given racial differences between these cohorts,

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11175620 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature