Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV.

ABSTRACT:

Background

The relationship between accelerated epigenetic aging and musculoskeletal outcomes in women with HIV (WWH) has not been studied.

Methods

We measured DNA methylation age using the Infinium MethylationEPIC BeadChip in a cohort from the Women's Interagency HIV Study (n = 190) with measures of bone mineral density (BMD) and physical function. We estimated 6 biomarkers of epigenetic aging-epigenetic age acceleration (EAA), extrinsic EAA, intrinsic EAA, GrimAge, PhenoAge, and DNA methylation-estimated telomere length-and evaluated associations of epigenetic aging measures with BMD and physical function. We also performed epigenome-wide association studies to examine associations of DNA methylation signatures with BMD and physical function.

Results

This study incl

SUBMITTER: Shiau S 

PROVIDER: S-EPMC11175700 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature