CDCA gene family promotes progression and prognosis in lung adenocarcinoma.

ABSTRACT:

Background

The cell division cycle-associated (CDCA) family participates in the cell cycle, and the dysregulation of its expression is associated with the development of several types of cancers. However, the roles of CDCAs in lung adenocarcinomas (LUAD) have not been investigated in systematic research.

Methods

Using data retrieved from The Cancer Genome Atlas (TCGA), the expression of CDCAs in LUAD and normal tissues was compared, and survival analysis was performed using the data. Also, the correlation between clinical characteristics and the expression of CDCAs was assessed. Using data from cBioPortal, we investigated genetic alterations in CDCAs and their prognostic implications. Immunohistochemical analyses were performed to validate our findings from TCGA data. Follow

SUBMITTER: Liu X 

PROVIDER: S-EPMC11175971 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature