Insights into polycrystalline microstructure of blood films with 3D Mueller matrix imaging approach.

ABSTRACT: This study introduces a novel approach in the realm of liquid biopsies, employing a 3D Mueller-matrix (MM) image reconstruction technique to analyze dehydrated blood smear polycrystalline structures. Our research centers on exploiting the unique optical anisotropy properties of blood proteins, which undergo structural alterations at the quaternary and tertiary levels in the early stages of diseases such as cancer. These alterations manifest as distinct patterns in the polycrystalline microstructure of dried blood droplets, offering a minimally invasive yet highly effective method for early disease detection. We utilized a groundbreaking 3D MM mapping technique, integrated with digital holographic reconstruction, to perform a detailed layer-by-layer analysis of partially depolarizing dry bl

SUBMITTER: Ushenko AG 

PROVIDER: S-EPMC11176350 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature