Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma (CCA) is a typical inflammation-induced malignancy, and elevated serum interleukin-6 (IL-6) levels have been reported to be linked to the onset and progression of CCA. We aim to investigate the potential prognostic value of the IL-6 pathway for CCA.

Methods

We detected the expressions of IL-6, IL-6R, glycoprotein (gp130), C-reactive protein (CRP), Janus kinase 2 (JAK2), and signal transducer and activator of transcription 3 (STAT3) in CCA tissue microarray using multiplex immunofluorescence. Furthermore, the clinical associations and prognostic values were assessed. Finally, single-cell transcriptome analysis was performed to evaluate the expression level of IL-6 pathway genes in CCA.

Results

The results revealed that the expression of IL

SUBMITTER: Gu D 

PROVIDER: S-EPMC11176422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature