On the effects of 30.5 GHz sinusoidal wave exposure on glioblastoma organoids.

ABSTRACT:

Introduction

Glioblastoma (grade IV) is the most aggressive primary brain tumor in adults, representing one of the biggest therapeutic challenges due to its highly aggressive nature. In this study, we investigated the impact of millimeter waves on tridimensional glioblastoma organoids derived directly from patient tumors. Our goal was to explore novel therapeutic possibilities in the fight against this challenging disease.

Methods

The exposure setup was meticulously developed in-house, and we employed a comprehensive dosimetry approach, combining numerical and experimental methods. Biological endpoints included a global transcriptional profiling analysis to highlight possible deregulated pathways, analysis of cell morphological changes, and cell phenotypic characterization w

SUBMITTER: Rampazzo E 

PROVIDER: S-EPMC11176452 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature