Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis.

ABSTRACT:

Background/aim

We employed Mendelian randomization (MR) analysis to investigate the causal relationship between the gut microbiota, acute pancreatitis, and potential inflammatory proteins.

Methods

The data for gut microbiota, acute pancreatitis, and inflammatory proteins are sourced from public databases. We conducted a bidirectional MR analysis to explore the causal relationship between gut microbiota and acute pancreatitis, and employed a two-step MR analysis to identify potential mediating inflammatory proteins. IVW is the primary analysis method, heterogeneity, pleiotropy, and sensitivity analyses were also conducted simultaneously.

Results

We identified five bacterial genera associated with the risk of acute pancreatitis, namely genus.Coprococcus3, genu

SUBMITTER: Huang P 

PROVIDER: S-EPMC11176513 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature