Genomic imputation of ancient Asian populations contrasts local adaptation in pre- and post-agricultural Japan.

ABSTRACT: Early modern humans lived as hunter-gatherers for millennia before agriculture, yet the genetic adaptations of these populations remain a mystery. Here, we investigate selection in the ancient hunter-gatherer-fisher Jomon and contrast pre- and post-agricultural adaptation in the Japanese archipelago. Building on the successful validation of imputation with ancient Asian genomes, we identify selection signatures in the Jomon, particularly robust signals from KITLG variants, which may have influenced dark pigmentation evolution. The Jomon lacks well-known adaptive variants (EDAR, ADH1B, and ALDH2), marking their emergence after the advent of farming in the archipelago. Notably, the EDAR and ADH1B variants were prevalent in the archipelago 1,300 years

SUBMITTER: Cooke NP 

PROVIDER: S-EPMC11176660 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature