Predictors and Risk Score for Immune Checkpoint-Inhibitor-Associated Myocarditis Severity.

ABSTRACT:

Background

Immune-checkpoint inhibitors (ICI) are associated with life-threatening myocarditis but milder presentations are increasingly recognized. The same autoimmune process that causes ICI-myocarditis can manifest concurrent generalized myositis, myasthenia-like syndrome, and respiratory muscle failure. Prognostic factors for this "cardiomyotoxicity" are lacking.

Methods

A multicenter registry collected data retrospectively from 17 countries between 2014-2023. A multivariable cox regression model (hazard-ratio(HR), [^95%confidence-interval]) was used to determine risk factors for the primary composite outcome: severe arrhythmia, heart failure, respiratory muscle failure, and/or cardiomyotoxicity-related death. Covariates included demographics, comorbidities, ca

SUBMITTER: Power JR 

PROVIDER: S-EPMC11177901 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature