Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease.

ABSTRACT:

Background

Neuropsychiatric symptoms are common and disabling in Parkinson's disease (PD), with troublesome anxiety occurring in one-third of patients. Management of anxiety in PD is challenging, hampered by insufficient insight into underlying mechanisms, lack of objective anxiety measurements, and largely ineffective treatments.In this study, we assessed the intracranial neurophysiological correlates of anxiety in PD patients treated with deep brain stimulation (DBS) in the laboratory and at home. We hypothesized that low-frequency (theta-alpha) activity would be associated with anxiety.

Methods

We recorded local field potentials (LFP) from the subthalamic nucleus (STN) or the globus pallidus pars interna (GPi) DBS implants in three PD cohorts: 1) patients with recordings

SUBMITTER: Swinnen BEKS 

PROVIDER: S-EPMC11177918 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature