Combining brain perturbation and neuroimaging in non-human primates.

ABSTRACT: Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible

SUBMITTER: Klink PC 

PROVIDER: S-EPMC11178240 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature