In silico CD4 + T-cell multiepitope prediction and HLA distribution analysis for Marburg Virus-A strategy for vaccine designing.

ABSTRACT: Marburg, a RNA virus (MRV), is responsible for causing hemorrhagic fever that affects humans and non-human primates. World Health Organization (WHO), National Institutes of Health (NIH) and Centre of Disease Control and Prevention (CDC) considered this as an extremely dangerous virus, thus categorised as risk group 4, category A priority pathogen and category "A" bioterrorism agent, respectively. Despite of all these alarming concerns, no prophylaxis arrangements are available against this virus till date. In fact, the construction of immunogenic vaccine candidates by traditional molecular immunology methods is time consuming and very expensive. Considering these concerns, herein, we have designed CD4 + T Cell multiepitopes against MRV using in silico approach. The pin-point criteri

SUBMITTER: Dhasmana A 

PROVIDER: S-EPMC11178283 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature