Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination.

ABSTRACT: Epithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in developmental and pathological processes. Although originally considered a binary event, EMT in cancer progression involves intermediate states between a fully epithelial and a fully mesenchymal phenotype, which are characterized by distinct combinations of epithelial and mesenchymal markers. This phenomenon has been termed epithelial to mesenchymal plasticity (EMP), however, the intermediate states remain poorly described and it's unclear whether they exist during developmental EMT. Neural crest cells (NCC) are an embryonic progenitor cell population that gives rise to numerous cell types and tissues in vertebrates, and their formation and delami

SUBMITTER: Zhao R 

PROVIDER: S-EPMC11178358 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature