Tailoring silk fibroin hydrophilicity and physicochemical properties using sugar alcohols for medical device coatings.

ABSTRACT: This study explores the modification of silk fibroin films for hydrophilic coating applications using various sugar alcohols. Films, prepared via solvent casting, incorporated glycerol, sorbitol, and maltitol, revealing distinctive transparency and UV absorption characteristics based on sugar alcohol chemical structures. X-ray diffraction confirmed a silk I to silk II transition influenced by sugar alcohols. Glycerol proved most effective in enhancing the β-sheet structure. The study also elucidated a conformational shift towards a β-sheet structure induced by sugar alcohols. Silk fibroin-sugar alcohol blind docking and sugar alcohol-sugar alcohol blind docking investigations were conducted utilizing the HDOCK Server. The computer simulation unveiled the significance of size and hydrogen b

SUBMITTER: Kaewpirom S 

PROVIDER: S-EPMC11178791 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature