Electron transport chain capacity expands yellow fever vaccine immunogenicity.

ABSTRACT: Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have identified correlates of vaccine immunogenicity that could be useful to guide development and selection of future vaccines. However, it remains unclear whether these findings represent mere statistical correlations or reflect functional associations with vaccine immunogenicity. Functional associations, rather than statistical correlates, would offer mechanistic insights into vaccine-induced adaptive immunity. Through a human experimental study to test the immunomodulatory properties of metformin, an anti-diabetic drug, we chanced upon a functional determinant of neutralizing antibodies. Although vaccine viremia is a known correlate of anti

SUBMITTER: Mok DZ 

PROVIDER: S-EPMC11178804 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature