Investigating the influence of perinatal fluoxetine exposure on murine gut microbial communities during pregnancy and lactation.

ABSTRACT: Selective Serotonin Reuptake Inhibitor (SSRI) therapy is common among perinatal populations for the treatment of mood disorders. Medications can affect diversity and composition of the gut microbiome, which plays a key role in modulating health. While previous studies have examined the effects of antidepressant exposure on the maternal gut microbiome, whether SSRI exposure affects the offspring gut microbiome is unknown. We investigated the effects of maternal fluoxetine exposure on the gut microbiome of maternal and offspring mice during pregnancy and lactation (embryonic day 10-lactation day 21; E10-L21). Stool samples collected on E17, L11, L15, and L21 were examined using 16S rRNA sequencing. Our results suggest that maternal fluoxetine exposure may result in decreased alpha diversity

SUBMITTER: Desorcy-Scherer K 

PROVIDER: S-EPMC11178873 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature