International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. bla_KPC-like was the most prevalent carbapenemase-encoding gene (46%), with bla_OXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differ

SUBMITTER: Budia-Silva M 

PROVIDER: S-EPMC11178878 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature