ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway.

ABSTRACT: The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 (B⁰AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and B⁰AT1. However, whether ACE2 and its binding protein B⁰AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/B⁰AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathw

SUBMITTER: Li J 

PROVIDER: S-EPMC11179371 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature