Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions.

ABSTRACT:

Background

Gut microbiota (GM) have been implicated as important regulators of gastrointestinal symptom which is commonly occurred along with respiratory influenza A virus (IAV) infection, suggesting the involvement of the gut-to-lung axis in a host's response to IAV. IAV primarily destroys airway epithelium tight junctions (TJs) and consequently causes acute respiratory disease syndrome. It is known that GM and their metabolism produce an anti-influenza effect, but their role in IAV-induced airway epithelial integrity remains unknown.

Methods

A mouse model of IAV infection was established. GM were analyzed using 16S rRNA gene sequencing, and short-chain fatty acids (SCFAs) levels were measured. GM depletion and fecal microbiota transplantation (FMT) were conducted to valida

SUBMITTER: Hu L 

PROVIDER: S-EPMC11179378 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature