A microbiota-directed complementary food intervention in 12-18-month-old Bangladeshi children improves linear growth.

ABSTRACT:

Background

Globally, stunting affects ∼150 million children under five, while wasting affects nearly 50 million. Current interventions have had limited effectiveness in ameliorating long-term sequelae of undernutrition including stunting, cognitive deficits and immune dysfunction. Disrupted development of the gut microbiota has been linked to the pathogenesis of undernutrition, providing potentially new treatment approaches.

Methods

124 Bangladeshi children with moderate acute malnutrition (MAM) enrolled (at 12-18 months) in a previously reported 3-month RCT of a microbiota-directed complementary food (MDCF-2) were followed for two years. Weight and length were monitored by anthropometry, the abundances of bacterial strains were assessed by quantifying metagenome-assembled g

SUBMITTER: Mostafa I 

PROVIDER: S-EPMC11179573 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature