The associations between synaptic density and "A/T/N" biomarkers in Alzheimer's disease: An ¹⁸F-SynVesT-1 PET/MR study.

ABSTRACT: A newly developed SV2A radiotracer, ¹⁸F-SynVesT-1, was used in this study to investigate synaptic density and its association with Alzheimer's disease (AD) "A/T/N" biomarkers. The study included a cohort of 97 subjects, consisting of 64 patients with cognitive impairment (CI) and 33 individuals with normal cognition (CU). All subjects underwent ¹⁸F-SynVesT-1 PET/MR and ¹⁸F-florbetapir PET/CT scans. Additionally, a subgroup of individuals also underwent ¹⁸F-MK-6240, ¹⁸F-FDG PET/CT, plasma Aβ42/Aβ40 and p-tau181 tests. The differences in synaptic density between the groups and the correlations between synaptic density and AD "A/T/N" biomarkers were analyzed. The results showed that compared to the CU group, the CI with Aβ+ (CI+) group ex

SUBMITTER: Li J 

PROVIDER: S-EPMC11179616 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature